Michael B Yaffe Selected Research

Phosphotransferases (Kinase)

1/2020	Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints.
11/2019	Substrate-based kinase activity inference identifies MK2 as driver of colitis.
1/2019	Pan-TAM Tyrosine Kinase Inhibitor BMS-777607 Enhances Anti-PD-1 mAb Efficacy in a Murine Model of Triple-Negative Breast Cancer.
10/2018	Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity.
1/2018	MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis.
10/2015	Tumor-Targeted Synergistic Blockade of MAPK and PI3K from a Layer-by-Layer Nanoparticle.
9/2014	Selective mitogen activated protein kinase activity sensors through the application of directionally programmable D domain motifs.
7/2013	mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin.
12/2011	Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop.
5/2010	Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations.

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Michael B Yaffe Research Topics

Disease

49	Neoplasms (Cancer) 10/2022 - 05/2002
13	Wounds and Injuries (Trauma) 10/2021 - 12/2014
9	COVID-19 02/2022 - 01/2020
7	Respiratory Insufficiency (Respiratory Failure) 02/2022 - 08/2015
7	Inflammation (Inflammations) 01/2020 - 08/2003
6	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 05/2020 - 08/2015
5	Carcinogenesis 01/2020 - 10/2003
4	Hemorrhage 12/2020 - 01/2019
4	Infections 08/2020 - 03/2005
3	Bacterial Infections (Bacterial Infection) 10/2021 - 03/2005
3	Sepsis (Septicemia) 10/2020 - 07/2003
3	Critical Illness (Critically Ill) 08/2020 - 01/2020
3	Neoplasm Metastasis (Metastasis) 01/2019 - 08/2014
3	Glioblastoma (Glioblastoma Multiforme) 01/2018 - 08/2006
3	Breast Neoplasms (Breast Cancer) 10/2015 - 07/2010
2	Thrombosis (Thrombus) 01/2020 - 01/2019
2	Colonic Neoplasms (Colon Cancer) 01/2020 - 01/2019
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2020 - 11/2013
2	Genomic Instability 01/2020 - 12/2005
2	Colitis 11/2019 - 12/2006
2	Insulin Resistance 01/2019 - 07/2013
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2019 - 07/2013
2	Triple Negative Breast Neoplasms 01/2019 - 05/2012
2	Ovarian Neoplasms (Ovarian Cancer) 01/2018 - 10/2003
2	Glioma (Gliomas) 01/2018 - 08/2006
2	Lung Neoplasms (Lung Cancer) 11/2015 - 05/2010
1	Brain Injuries (Brain Injury) 12/2021
1	Hemorrhagic Shock 12/2020
1	Lymphoid Leukemia 10/2020
1	Virus Diseases (Viral Diseases) 01/2020
1	Fever (Fevers) 01/2020
1	Lethargy 01/2020
1	Lung Injury 01/2020
1	Coinfection 01/2020
1	Adenocarcinoma of Lung 01/2020

Drug/Important Bio-Agent (IBA)

15	Phosphotransferases (Kinase)IBA 01/2020 - 05/2002
10	Tissue Plasminogen Activator (Alteplase)FDA Link 02/2022 - 01/2019
10	DNA (Deoxyribonucleic Acid)IBA 10/2021 - 12/2005
7	Proteins (Proteins, Gene)FDA Link 01/2020 - 10/2003
6	Pharmaceutical PreparationsIBA 10/2021 - 03/2013
5	Tranexamic Acid (AMCA)FDA Link 12/2020 - 01/2019
5	Fibrinolysin FDA Link 12/2020 - 01/2019
5	CytokinesIBA 10/2020 - 10/2015
5	RNA (Ribonucleic Acid)IBA 01/2020 - 11/2015
5	Peptides (Polypeptides)IBA 01/2020 - 07/2013
5	Cisplatin (Platino)FDA LinkGeneric 01/2020 - 02/2007
5	Small Interfering RNA (siRNA)IBA 01/2020 - 10/2008
4	MAP-kinase-activated kinase 2IBA 01/2020 - 08/2003
4	Protein Isoforms (Isoforms)IBA 01/2019 - 05/2005
3	Biomarkers (Surrogate Marker)IBA 12/2021 - 01/2019
3	Complement System Proteins (Complement)IBA 01/2021 - 01/2019
3	p38 Mitogen-Activated Protein KinasesIBA 01/2020 - 08/2003
3	PlatinumIBA 01/2020 - 01/2017
3	Transcription Factors (Transcription Factor)IBA 01/2018 - 02/2010
3	14-3-3 Proteins (14-3-3 Protein)IBA 01/2012 - 09/2004
3	Tyrosine (L-Tyrosine)FDA Link 01/2009 - 08/2006
2	Immune Checkpoint InhibitorsIBA 01/2022 - 10/2021
2	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2021 - 02/2007
2	Oxygen (Dioxygen)IBA 01/2020 - 01/2008
2	Protein Kinases (Protein Kinase)IBA 01/2020 - 09/2014
2	LipopolysaccharidesIBA 01/2020 - 08/2015
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019 - 01/2008
2	Insulin (Novolin)FDA Link 01/2019 - 07/2003
2	Matrix Metalloproteinases (MMPs)IBA 01/2019 - 08/2015
2	Histones (Histone)IBA 01/2019 - 09/2012
2	RNA-Binding Proteins (RNA-Binding Protein)IBA 12/2015 - 11/2015
2	Oncogene Proteins (Oncogene Protein)IBA 08/2014 - 01/2012
2	Mechanistic Target of Rapamycin Complex 1IBA 07/2013 - 06/2011
2	Phosphatidylinositols (Phosphatidylinositol)IBA 06/2011 - 08/2009
2	ErbB Receptors (EGF Receptor)IBA 05/2010 - 01/2009
2	Neurofibromin 2 (Merlin)IBA 10/2008 - 10/2003
2	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2008 - 03/2005
2	LigandsIBA 08/2006 - 09/2004
1	Oxidoreductases (Dehydrogenase)IBA 01/2022
1	Heparin (Liquaemin)FDA LinkGeneric 01/2022
1	Ubiquitin Thiolesterase (Ubiquitin Carboxy-Terminal Hydrolase)IBA 12/2021
1	Heme (Haem)IBA 10/2021
1	Etoposide (VP 16)FDA LinkGeneric 10/2021
1	Mitoxantrone (Novantrone)FDA LinkGeneric 10/2021
1	AntibodiesIBA 10/2021
1	SC5b-9 protein complexIBA 12/2020
1	Cysteine (L-Cysteine)FDA Link 10/2020
1	Aurora Kinase AIBA 10/2020
1	Adenosine Triphosphate (ATP)IBA 10/2020
1	Antiviral Agents (Antivirals)IBA 05/2020
1	Anti-Bacterial Agents (Antibiotics)IBA 05/2020
1	estropipate (Ogen)FDA LinkGeneric 03/2020
1	Lysine (L-Lysine)FDA Link 03/2020
1	fibrin fragment D (D-dimer)IBA 01/2020
1	ChromatinIBA 01/2020
1	Poly I-CIBA 01/2020
1	ThrombomodulinIBA 01/2020

Therapy/Procedure

21	Therapeutics 10/2022 - 08/2006
8	Drug Therapy (Chemotherapy) 01/2020 - 08/2009
4	Artificial Respiration (Mechanical Ventilation) 08/2020 - 08/2015
3	Critical Care (Surgical Intensive Care) 11/2020 - 08/2015
2	Immunotherapy 01/2022 - 04/2015
2	Thrombolytic Therapy 05/2020 - 01/2020
1	Resuscitation 03/2020
1	Mechanical Ventilators (Ventilator) 01/2020